Fetuin-B, also known asFetuin-like protein IRL685 and FETUB, is a secreted protein which belongs tothefetuin family. Fetuin-B / FETUB contains twocystatin domains.Fetuin-B is a member of the fetuin family, part of the cystatin superfamily ofcysteine protease inhibitors. Fetuins have been implicated in several diversefunctions, including osteogenesis and bone resorption. Fetuin-A has been identified as a major protein during fetal lifeand is also involved in important functions such as protease inhibitory activities anddevelopment-associated regulation of calcium metabolism and osteogenesis.Fetuin-A is a key partner in the recovery phase of an acute inflammatoryresponse. Fetuin-B / FETUB is found at least in human and rodents. It isunambiguously a paralogue of Fetuin-A. Fetuin-A and Fetuin-B exhibitsignificant differences at the amino acid sequence level, notably includingvariations with respect to the archetypal fetuin-specific signature.

fetuin B