商品介绍
FGF1 Protein, Human, Recombinant: Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 50-200 pg/ml.
Protein Construction
A DNA sequence encoding the mature form of human FGF acidic (AAA79245.1) (Phe 16-Asp 155) was expressed, with an additional Met at the N-terminus.
Accession#
AAA79245.1
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met 1
Molecule Mass
The recombinant human FGF acidic consists of 141 amino acids and has a calculated molecular mass of 16 kDa as estimated by SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FGF1 Protein, Human, Recombinant: Images
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 50-200 pg/ml.
FGF1 Protein, Human, Recombinant: Synonyms
AFGF Protein, Human; ECGF Protein, Human; ECGF-beta Protein, Human; ECGFA Protein, Human; ECGFB Protein, Human; FGF-1 Protein, Human; FGF-alpha Protein, Human; FGFA Protein, Human; GLIO703 Protein, Human; HBGF-1 Protein, Human; HBGF1 Protein, Human
FGF1 Background Information
aFGF, also known as FGF1 and HBGF-1, is a member of the fibroblast growth factor family. The biological activity of aFGF protein is exerted through binding to four high affinity cell surface receptors (FGFR1–4), which results in receptor dimerization and transphosphorylation in the tyrosine kinase domain. aFGF protein shows a wide range of endocrine-like activities. As a multiple function growth factor, this protein is involved in embryo development and tissue repair. Additionally, this protein is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer.
References
Full Name
fibroblast growth factor 1 (acidic)
Related Pathways
Actin Dynamics Signaling Pathway
G Protein-coupled Receptors Signaling
MAPK-Erk Pathway
Autophagy Pathway
References
- Jaye M., et al.,(1986), Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science 233:541-545.
- Mergia A., et al., (1989), Structural analysis of the gene for human acidic fibroblast growth factor.Biochem. Biophys. Res. Commun. 164:1121-1129.
- Wang W.P., et al.,(1989), Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.Mol. Cell. Biol. 9:2387-2395.
Cynomolgus FGF1 Proteins
- FGF1 Protein, Cynomolgus, Recombinant90062-CNAE
Mouse, Rat FGF1 Proteins
- FGF1 Protein, Mouse, Rat, Recombinant50179-MNAE
Canine FGF1 Proteins
- FGF1 Protein, Canine, Recombinant70039-DNAE
- miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cellsAuthorNi, Y;Zhang, K;Liu, X;Yang, T;Wang, B;Fu, L;Year2014JournalNeural RegenerationResearchApplicationthe cuture of neural crest stem cells; the induction of hair follicle-derived neural crest stem cells differentied into Schwann cellsPubMed ID: 25206896FoldedExpand
- Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signalingAuthorLi, XY;Tao, H;Jin, C;DU, ZY;Liao, WF;Tang, QJ;Ding, K;Year2020JournalChin J Nat MedApplicationSPRPubMed ID: 32451092FoldedExpand
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