商品介绍
PDGFRB Matched ELISA Antibody Pair Set,Human General Information
Product name
PDGFRB Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human PDGFRB
Assay range
62.5-4000 pg/mL
Materials provided
1. Capture Antibody 0.3 mg/mL of mouse anti-PDGFRb monoclonal antibody. Dilute to a working concentration of 2 μg/mL in CBS before coating. (Catalog: # 10514-MM06)2. Detection Antibody 0.5 mg/mL of mouse anti-PDGFRb monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to a working concentration of 0.8 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10514-MM08)3. Standard Each vial contains 40 ng of recombinant PDGFRb. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve usi ng 2-fold serial dilutions in sample dilution buffer, and a high standard of 4 ng/mL is recommended
Product overview
This PDGFRB Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human PDGFRB . It contains Human PDGFRB capture antibody, Human PDGFRB detector antibody (HRP)and a highly purifiedHEK293-expressedrecombinant Human PDGFRB protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
PDGFRB Matched ELISA Antibody Pair Set,Human Images
PDGFRB Matched ELISA Antibody Pair Set,Human: Synonyms
CD140B Matched ELISA Antibody Pair Set, Human; IBGC4 Matched ELISA Antibody Pair Set, Human; IMF1 Matched ELISA Antibody Pair Set, Human; JTK12 Matched ELISA Antibody Pair Set, Human; KOGS Matched ELISA Antibody Pair Set, Human; PDGFR Matched ELISA Antibody Pair Set, Human; PDGFR-1 Matched ELISA Antibody Pair Set, Human; PDGFR1 Matched ELISA Antibody Pair Set, Human; PENTT Matched ELISA Antibody Pair Set, Human
PDGFRB Background Information
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
platelet-derived growth factor receptor, beta polypeptide
Research Areas
- Cancer Drug Targets
- Receptor Tyrosine Kinases (RTKs)
References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.
- Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF‐α‐induced inflammation and associated molecular markers in human …AuthorJA Giménez‐Bastida…Year2012JournalMol. Nutr. Food Res.ApplicationMeasurement of adhesion molecules, growth factors and cytokines by enzyme-linked immunosorbent assay (ELISA)FoldedExpand
- Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblastsAuthorJA Giménez-Bastida, M Larrosa…Year2012JournalJ. Agric. Food Chem.ApplicationMeasurement of Growth Factors, Adhesion Molecules, and Cytokines by ELISAPubMed ID: 22463485FoldedExpand
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