商品介绍
CD200 Matched ELISA Antibody Pair Set,Human General Information
Product name
CD200 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human CD200
Assay range
46.88-3000 pg/mL
Materials provided
1. Capture Antibody 1 mg/mL of rabbit anti-Human CD200 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10886-R005)2. Detection Antibody 0.2 mg/mL of rabbit anti-Human CD200 polyclonalantibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use.3. Standard Each vial contains 190 ng of recombinant Human CD200. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3000 pg/mL is recommended.
Product overview
This CD200 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CD200 . It contains Human CD200 capture antibody, Human CD200 detector antibody (HRP)and a highly purifiedHEK293-expressedrecombinant Human CD200 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
CD200 Matched ELISA Antibody Pair Set,Human Images
CD200 Matched ELISA Antibody Pair Set,Human: Synonyms
MOX1 Matched ELISA Antibody Pair Set, Human; MOX2 Matched ELISA Antibody Pair Set, Human; MRC Matched ELISA Antibody Pair Set, Human; OX-2 Matched ELISA Antibody Pair Set, Human; OX2 Matched ELISA Antibody Pair Set, Human
CD200 Background Information
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson"s disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
Cd200 molecule
Research Areas
- Neuroinflammation
- Cancer Drug Targets
References
- Minas K, et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit Rev Immunol. 26(3): 213-30.
- Wang XJ, et al. (2007) CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson"s disease. J Neuroimmune Pharmacol. 2(3): 259-64.
- Wong KK, et al. (2010) The role of CD200 in immunity to B cell lymphoma. J Leukoc Biol. 88(2): 361-72.
- Omalizumab is effective in treating severe asthma in patients with severe cardiovascular complications and its effects on sCD200, d-dimer, CXCL8, 25-hydroxyvitamin D and IL-1β levelsAuthorYalcin, AD;Cilli, A;Bisgin, A;Strauss, LG;Herth, F;Year2013JournalExpert Opin Biol TherApplicationELISAPubMed ID: 23883435FoldedExpand
- There might be a role for CD200 in the pathogenesis of autoimmune and inflammatory skin disordersAuthorAkman-Karakaş, A;Yalcin, AD;Koç, S;Gumuslu, S;Senol, YY;Özkesici, B;Genc, GE;Ergun, E;Ongut, G;Yilmaz, E;Uzun, S;Alpsoy, E;Year2013JournalMed. Sci. Monit.ApplicationELISA (serum)PubMed ID: 24157657FoldedExpand
- Evaluation of d-dimer, CXCL8, homocysteine, eosinophil cationic peptide, 25(OH)-vitamin D, and immunomodulatory OX-2 levels in allergic patientsAuthorYalcin, AD;Tural Onur, S;Celik, B;Gumuslu, S;Year2014JournalJ AsthmaApplicationELISAPubMed ID: 24986253FoldedExpand
- Evaluation of soluble CD200 levels in type 2 diabetic foot and nephropathic patients: association with disease activityAuthorArik, HO;Yalcin, AD;Celik, B;Seyman, D;Tetik, G;Gursoy, B;Kose, S;Gumuslu, S;Year2014JournalMed. Sci. Monit.ApplicationELISAPubMed ID: 24964809FoldedExpand
- Proteomics pattern of peritoneal sApo-2L but not CD200 (OX-2) as a possible screening biomarker for metastatic ovarian, endometrial and breast carcinomaAuthorCelik, B;Didem Yalcin, A;Esra Genc, G;Gumuslu, S;Year2015JournalJ BUONApplicationELISA for determination of sCD200 concentration in the serum samplesPubMed ID: 25778329FoldedExpand
- Effects of Omalizumab Treatment on Some Biomarkers in Severe Allergic Asthma PatientsAuthorÖnür, ST;Yalçın, AD;Gümüşlü, S;Genç, GE;Kiraz, K;Altın, S;Year2017JournalEurasİan journal of pulmonologyApplicationElisaFoldedExpand
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