商品介绍
FOXC2 cDNA ORF Clone, Human, untagged: General Information
Gene
Species
Human
NCBI Ref Seq
NM_005251.2
RefSeq ORF Size
1506 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human forkhead box C2.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Restriction Sites
KpnI + XbaI(6kb+1.51kb)
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" ) BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
FOXC2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
More Information About FOXC2
Entrez Gene ID
2303
FOXC2 cDNA ORF Clone, Human, untagged: Validated Images
FOXC2 cDNA ORF Clone, Human, untagged: Synonyms
FKHL14 cDNA ORF Clone, Human; LD cDNA ORF Clone, Human; MFH-1 cDNA ORF Clone, Human; MFH1 cDNA ORF Clone, Human
FOXC2 Background Information
Forkhead box protein C2 (FOXC2), a transcription factor of the forkhead/winged-helix family, is required for embryonic development and many other key physiological processes, such as osteoblast differentiation, lymphangiogenesis, and angiogenesis. FOXC2 was reported to function as an epithelial-to-mesenchymal transition (EMT) related gene during not only tumor progression but also organ repair. FOXC2 is overexpressed in patients with esophageal cancer and cholangiocarcinoma, and a high expression of FOXC2 in tumor tissues is related to cancer progression and a poor prognosis. These data were consistent with other cancers, including breast, colorectal, nasopharyngeal, esophageal, lung, ovarian, cholangiocarcinoma, and osteosarcoma.
Full Name
forkhead box C2
References
- Wang T, et al. (2018) Emerging roles and mechanisms of foxc2 in cancer. Clin Chim Acta 479 84-93.
- Shimoda Y, et al. (2018) High expression of forkhead box protein c2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma. BMC Cancer 18 (1): 597.
- Nilsson D, et al. (2019) Foxc2 is essential for podocyte function. Physiol Rep 7 (9): e14083.
FOXC2 cDNA ORF Clone, Human,Related Products
- FOXC2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG18185-ACGLN
- LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca2+-FAK signal pathwayAuthorPan, K;Xie, Y;Year2020JournalCell Death DisApplicationcomplatePubMed ID: 32513911FoldedExpand
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