商品介绍
Anti-TNF-alpha Antibody, Rabbit Polyclonal General Information
Product name
Anti-TNF-alpha Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat TNF-alpha
Immunogen
Recombinant Rat TNF-alpha protein (Catalog#80045-RNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Rat TNF-alpha (rR TNF-alpha; Catalog#80045-RNAE; P16599; Leu 80-Leu 235). TNF-alpha specific IgG was purified by Rat TNF-alpha affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-TNF-alpha Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:5000-1:10000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
TNF-alpha Background Information
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.TNF-alpha Protein & Antibody
TNF-alpha Protein & Antibody- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
tumor necrosis factor
Research Areas
- Cancer Drug Targets
- Neuroinflammation
Related Pathways
Death Receptor Signaling
NF-kB (NFkB) Pathway
IL17 signaling pathway
References
- Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
- Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
- Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the ratAuthorLiu, F;Wang, Z;Qiu, Y;Wei, M;Li, C;Xie, Y;Shen, L;Huang, Y;Ma, C;Year2017JournalJ NeuroinflammationApplicationWBPubMed ID: 28359290FoldedExpand
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