商品介绍
DPEP1 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human DPEP1 (P16444) (Met1-Ser385) was expressed with a polyhistidine tag at the C-terminus.
Accession#
P16444
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Asp 17
Molecule Mass
The recombinant human DPEP1 consists of 380 amino acids and predicts a molecular mass of 42.5 KDa. It migrates as an approximately 44-47 KDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
DPEP1 Protein, Human, Recombinant (His Tag): Images
DPEP1 Protein, Human, Recombinant (His Tag): Synonyms
MBD1 Protein, Human; MDP Protein, Human; RDP Protein, Human
DPEP1 Background Information
Dehydropeptidase-I, also known as DPEP1, is a kidneymembrane enzyme. Its expression in normal colonic mucosa is very low, but it ishighly expressed in colorectal adenoma and cancer specimens and is negativelycorrelated with parameters of pathological aggressiveness and poor prognosis.The overexpression of DPEP1 suppressed tumor cellsinvasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatmentdecreased DPEP1 expression. Dehydropeptidase-I may be a candidate target in PDACfor designing improved treatments. It uses zinc as a cofactor and acts as adisulfide-linked homodimer.
Full Name
dipeptidase 1
References
- Toiyama Y. et al., 2011, J Gastroenterol. 46 (2): 153-63.
- Zhang G. et al., 2012, PLoS One. 7 (2): e31507.
- Okamoto T. et al., 2011, Mod Pathol. 24 (2): 267-76.
- Monoclonal antibody binding-site diversity assessment with a cell-based clustering assayAuthorLiao-Chan, S;Zachwieja, J;Gomez, S;Duey, D;Lippincott, J;Theunissen, JW;Year2013JournalJ. Immunol. MethodsApplicationHybridoma supernatant off-rate screeningPubMed ID: 24380699FoldedExpand
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