商品介绍
STAT6 Protein, Human, Recombinant (His Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE
Endotoxin
< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human STAT6 isoform 1 (P42226-1) (Met 1-Trp 847) was fused with a polyhistidine tag at the C-terminus.
Accession#
P42226-1
Expressed Host
Baculovirus-Insect Cells
Species
Human
Predicted N Terminal
Ser 2
Molecule Mass
The recombinant human STAT6 consists of 857 amino acids and predicts a molecular mass of 95.5 kDa. It migrates as an approximately 100 kDa band in SDS-PAGE in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 0.3mM DTTPlease contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
STAT6 Protein, Human, Recombinant (His Tag): Images
STAT6 Protein, Human, Recombinant (His Tag): Synonyms
D12S1644 Protein, Human; IL-4-STAT Protein, Human; STAT6B Protein, Human; STAT6C Protein, Human
STAT6 Background Information
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.
Full Name
signal transducer and activator of transcription 6, interleukin-4 induced
Research Areas
- Apoptosis Transcription Factors and Regulators
Related Pathways
Jak-Stat Signaling Pathway
Common G-Chain signaling pathway
References
- Litterst CM, et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.
- Stutz AM, et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91.
- Yang J, et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.
- PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylationAuthorIwata, H;Goettsch, C;Sharma, A;Ricchiuto, P;Goh, WW;Halu, A;Yamada, I;Yoshida, H;Hara, T;Wei, M;Inoue, N;Fukuda, D;Mojcher, A;Mattson, PC;Barabási, AL;Boothby, M;Aikawa, E;Singh, SA;Aikawa, M;Year2016JournalNat CommunApplicationsubstratePubMed ID: 27796300FoldedExpand
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