商品介绍
TNFR2/TNFRSF1B Protein, Mouse, Recombinant (His Tag): Product Information
Purity
> 97 % as determined by SDS-PAGE
Endotoxin
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Activity
Measured by its ability to inhibit TNFα-mediated cytotoxicity in L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is typically 1-3 μg/mL in the presence of 0.1 ng/mL of recombinant mouse TNFα.
Protein Construction
A DNA sequence encoding the extracellular domain of mouse TNFRSF1B (NP_035740.2) (Met 1-Gly 258) was fused with a polyhistidine tag at the C-terminus.
Accession#
NP_035740.2
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Val 23
Molecule Mass
The recombinant mouse TNFRSF1B consists of 247 amino acids and has a predicted molecular mass of 26.8 kDa. In SDS-PAGE under reducing conditions, rm TNFRSF1B migrates as an approximately 45 kDa band due to glycosylation.
Formulation
Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TNFR2/TNFRSF1B Protein, Mouse, Recombinant (His Tag): Images
Measured by its ability to inhibit TNFα-mediated cytotoxicity in L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is typically 1-3 μg/mL in the presence of 0.1 ng/mL of recombinant mouse TNFα.
TNFR2/TNFRSF1B Protein, Mouse, Recombinant (His Tag): Synonyms
CD120b Protein, Mouse; p75 Protein, Mouse; TNF-alphaR2 Protein, Mouse; TNF-R-II Protein, Mouse; TNF-R2 Protein, Mouse; TNF-R75 Protein, Mouse; TNFalpha-R2 Protein, Mouse; TNFBR Protein, Mouse; Tnfr-1 Protein, Mouse; Tnfr2 Protein, Mouse; TNFR80 Protein, Mouse; TNFRII Protein, Mouse
TNFR2/TNFRSF1B Background Information
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
tumor necrosis factor receptor superfamily, member 1b
Research Areas
- Neuroinflammation
References
- Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
- Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
- Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
Human TNFR2/TNFRSF1B Proteins
- TNFR2/TNFRSF1B Protein, Human, Recombinant (ECD, His Tag), Biotinylated10417-H08H-B
- TNFR2/TNFRSF1B Protein, Human, Recombinant (ECD, His Tag)10417-H08H
- TNFR2/TNFRSF1B Protein, Human, Recombinant (aa 1-268, 196 Met/Arg, His Tag)10417-H08H1
- TNFR2/TNFRSF1B Protein, Human, Recombinant (ECD, His & hFc Tag)10417-H03H
Mouse TNFR2/TNFRSF1B Proteins
- TNFR2/TNFRSF1B Protein, Mouse, Recombinant (hFc Tag)50128-M02H
Cynomolgus, Rhesus TNFR2/TNFRSF1B Proteins
- TNFR2/TNFRSF1B Protein, Cynomolgus, Rhesus, Recombinant (hFc Tag)90102-C02H
- TNFR2/TNFRSF1B Protein, Cynomolgus, Rhesus, Recombinant (His Tag)90102-C08H
- Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cellsAuthorLu, Y;Xu, X;Jiang, T;Jin, L;Zhao, XD;Cheng, JH;Jin, XJ;Ma, J;Piao, HN;Piao, LX;Year2018JournalInt. Immunopharmacol.PubMed ID: 30544065FoldedExpand
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