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ESRP1/RBM35A cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_017697.3
RefSeq ORF Size
2046 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 984C/T not causing the amino acid variation;108A/T(L36N).
Description
Full length Clone DNA of Human epithelial splicing regulatory protein 1.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
ESRP1/RBM35A cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
ESRP1/RBM35A cDNA ORF Clone in Cloning Vector, Human: Synonyms
RBM35A cDNA ORF Clone, Human; RMB35A cDNA ORF Clone, Human
ESRP1/RBM35A Background Information
Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific RNA binding protein that controls several key cellular processes, like alternative splicing and translation. Epithelial splicing regulatory protein 1 (ESRP1) has been characterized as an essential splicing factor required for the regulation of human pluripotency and differentiation. ESRP1 regulates CD44 alternative splicing during the EMT process which plays an important role in EOC carcinogenesis. In addition, ESRP1 is associated with disease prognosis in epithelial ovarian cancer (EOC). Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2), epithelial cell-specific regulators of alternative splicing, are downregulated during the epithelial-mesenchymal transition (EMT). There is a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis.
Full Name
epithelial splicing regulatory protein 1
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- Regulation of carcinoma cell motility by the GTPase isoforms Rac1 and Rac1bAuthorund Rac1b, GTPIR;Year2020JournalThesisApplicationtemplateFoldedExpand
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